CYTOGENETIC STUDIES ON CHRONIC MYELOCYTIC LEUKEMIA
نویسندگان
چکیده
منابع مشابه
Clinical implications of cytogenetic variants in chronic myelocytic leukemia (CML).
By JACQUELINE WHANG-PENG, GEORGE P. CANELLOS, PAUL P. CARBONE AND J. H. Tjio T HE Ph’ CHROMOSOME, with the exception of a few cases of acute leukemia,’5 occurs only in patients with chronic myelocytic leukemia and is still the only consistent chromosome abnormality found in neoplastic diseases.4’9 In about 85 per cent of patients with CML, the Ph1 chromosome is found in most if not all marrow c...
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Cytogenetic studies were carried out on 103 unselected patients with acute mye-logenous leukemia (AML) at the Clinical Center of the National Institutes of Health. Seventy-three patients (70.9%) had a normal karyotype and 30 patients (29.1%) were aneuploid. No unique chromosomal abnormalities were found in patients with aneuploidy; however, there was a significantly higher incidence of G group ...
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Cytogenetic studies were performed on three patients with chronic T cell leukemia and on one patient with T cell lymphoma. One of the patients had leukemic cells derived from a suppressor T cell clone, another expressed OKT3, 4, and 8, and cells of the other two were derived from a helper T cell clone. All patients had an abnormal karyotype in peripheral blood or bone marrow cultured with or wi...
متن کاملPersistence of Chronic Myelocytic Leukemia
Chronic myelocytic leukemia (CML)' is a clonal pluripotent stem cell disease, clinically divided into a chronic phase of a median duration of ^-4 yr, followed by an acute phase (blast crisis) lasting for few months (1) . Cytogenetic hallmark of most (95%) CML cases is the presence of the Philadelphia (Ph) chromosome, resulting from a reciprocal translocation between chromosomes 9 and 22 (2, 3) ...
متن کاملFetal erythropoiesis in juvenile chronic myelocytic leukemia.
Red cell enzymes, 2,3-diphosphoglycerate (2,3-DPG) and adenosine triphosphate (ATP), were evaluated in a 23-mo-old boy with juvenile chronic myelocytic leukemia (JCML) at the onset of his illness and 6 mo later during the accelerated phase. The activities of the age-dependent red cell enzymes, hexokinase, aldolase, pyruvate kinase, and glucose-6-phosphate dehydrogenase, were elevated, as were t...
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ژورنال
عنوان ژورنال: Nihon Naika Gakkai Zasshi
سال: 1972
ISSN: 0021-5384,1883-2083
DOI: 10.2169/naika.61.800